1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid

Base Information

• Chemical Name: 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid
• CAS No.: 423158-39-8
• Molecular Formula: C₂₅H₁₆N₂O₂
• Molecular Weight: 376.414

Synonyms:1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid

Chemical Property of 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid

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Technology Process of 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid

There total 5 articles about 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaldehyde (423158-38-7) → 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid (423158-39-8)

Guidance literature:

With potassium permanganate; In water; acetone; for 1h; Heating;

DOI:10.1002/jhet.5570380605

Reference yield:

4-chloro-2-phenylquinazoline (6484-25-9) → 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid (423158-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / Pd(PPh₃)4; aq. K₂CO₃ / 1,2-dimethoxy-ethane / Heating

2: NBS; dibenzoyl peroxide / CCl₄ / 6 h / Heating; irradiated

3: 0.25 g / aq. AgNO₃ / ethanol; tetrahydrofuran / 1 h / Heating

4: 70 percent / KMnO₄ / acetone; H₂O / 1 h / Heating

With potassium permanganate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; silver nitrate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; acetone; 1: Suzuki coupling;

DOI:10.1002/jhet.5570380605

Reference yield:

2-methyl-1-naphthylboronic acid (103989-84-0) → 1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaxylic acid (423158-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / Pd(PPh₃)4; aq. K₂CO₃ / 1,2-dimethoxy-ethane / Heating

2: NBS; dibenzoyl peroxide / CCl₄ / 6 h / Heating; irradiated

3: 0.25 g / aq. AgNO₃ / ethanol; tetrahydrofuran / 1 h / Heating

4: 70 percent / KMnO₄ / acetone; H₂O / 1 h / Heating

With potassium permanganate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; silver nitrate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; acetone; 1: Suzuki coupling;

DOI:10.1002/jhet.5570380605

upstream raw materials:

1-(2-phenyl-quinizolin-4-yl)-naphthalene-2-carbaldehyde

4-chloro-2-phenylquinazoline

2-methyl-1-naphthylboronic acid

4-(2-methyl-naphthalen-1-yl)-2-phenyl-quinazoline

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