2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Base Information

Chemical Name:2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide
CAS No.:1477811-16-7
Molecular Formula:C₂₄H₂₉ClN₂O₃
Molecular Weight:428.959
Hs Code.:

Synonyms:2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

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Chemical Property of 2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

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Technology Process of 2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

There total 4 articles about 2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 15992-10-6
2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide

: 1477811-19-0
1-(chloromethyl)-2-((5-chloropentyl)oxy)benzene

: 1477811-16-7
2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

1-(chloromethyl)-2-((5-chloropentyl)oxy)benzene; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/cjoc.201300079

Reference yield:

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 1477811-16-7
2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -10 °C

1.2: 0.5 h

2.1: ammonium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 20 °C

With 4-methyl-morpholine; ammonium hydroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201300079

Reference yield:

: 6264-33-1
Indomethacin amide

: 1477811-16-7
2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 20 °C

With sodium hydride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201300079