2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Base Information

Chemical Name:2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide
CAS No.:1477811-25-8
Molecular Formula:C₃₈H₄₀N₄O₄
Molecular Weight:616.76
Hs Code.:

Synonyms:2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

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Chemical Property of 2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

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Technology Process of 2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

There total 6 articles about 2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 7677-24-9
trimethylsilyl cyanide

: 1477811-21-4
2-(1-(2-((5-(2-formylphenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

: 62-53-3
aniline

: 1477811-25-8
2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: 2-(1-(2-((5-(2-formylphenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide; aniline; In acetonitrile; for 0.166667h;

trimethylsilyl cyanide; With iodine; In acetonitrile; at 20 ℃;
DOI:10.1002/cjoc.201300079

Reference yield:

: 1477811-16-7
2-(1-(2-((5-chloropentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

: 1477811-25-8
2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 12 h / Reflux

2.1: acetonitrile / 0.17 h

2.2: Strecker Aminoacid Synthesis / 20 °C

With potassium carbonate; In acetonitrile; 2.1: |Strecker Aminoacid Synthesis;
DOI:10.1002/cjoc.201300079

Reference yield:

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 1477811-25-8
2-(1-(2-((5-(2-(cyano(phenylamino)methyl)phenoxy)pentyl)oxy)benzyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -10 °C

1.2: 0.5 h

2.1: ammonium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 20 °C

5.1: potassium carbonate / acetonitrile / 12 h / Reflux

6.1: acetonitrile / 0.17 h

6.2: Strecker Aminoacid Synthesis / 20 °C

With 4-methyl-morpholine; ammonium hydroxide; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 6.1: |Strecker Aminoacid Synthesis;
DOI:10.1002/cjoc.201300079