7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Base Information

Chemical Name:7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester
CAS No.:950524-57-9
Molecular Formula:C₃₈H₄₃FN₂O₅
Molecular Weight:626.768
Hs Code.:

Synonyms:7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

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Chemical Property of 7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

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Technology Process of 7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

There total 8 articles about 7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: cis-(6-{2-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

: trans-(6-{2-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

: 950524-57-9
7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: cis-(6-{2-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester; trans-(6-{2-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester; With hydrogen; palladium 10% on activated carbon; In methanol; for 3h; under 2585.81 Torr;

With hydrogenchloride; methanol; water; at 25 ℃; for 3h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: C₃₈H₄₁FN₂O₅

: 950524-57-9
7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 6h;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 889878-64-2
1-(4-fluoro-phenyl)-2-hydroxymethyl-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

: 950524-57-9
7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / CH₂Cl₂ / 2 h / 50 °C

2: 65 percent / n-BuLi / tetrahydrofuran / 2 h / -78 - 25 °C

3: 81 percent / HCl / methanol / 12 h / 25 °C

4: H₂ / Pd/C / ethanol / 6 h / 25 °C

With hydrogenchloride; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.097