1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

Base Information

Chemical Name:1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one
CAS No.:889878-62-0
Molecular Formula:C₂₇H₂₃FN₂O
Molecular Weight:410.491
Hs Code.:

Synonyms:1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

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Chemical Property of 1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

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Technology Process of 1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

There total 1 articles about 1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 889878-61-9
3-(2-bromomethyl-phenyl)-4-(4-fluoro-phenyl)-1-isopropyl-1H-pyrrole-2-carboxylic acid phenylamide

: 889878-62-0
1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 24.5h;

Reference yield: 80.0%

: 889878-62-0
1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 889878-63-1
1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulene-2-carbaldehyde

Guidance literature:: With trichlorophosphate; In 1,2-dichloro-ethane; at 80 ℃; for 18h;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 889878-62-0
1-(4-fluoro-phenyl)-3-isopropyl-5-phenyl-5,6-dihydro-3H-3,5-diaza-benzo[e]azulen-4-one

: 950524-57-9
7-[1-(4-fluoro-phenyl)-3-isopropyl-4-oxo-5-phenyl-3,4,5,6-tetrahydro-3,5-diaza-benzo[e]azulen-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

2: 67 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0.5 h / 0 °C

3: 100 percent / CH₂Cl₂ / 2 h / 50 °C

4: 65 percent / n-BuLi / tetrahydrofuran / 2 h / -78 - 25 °C

5: 81 percent / HCl / methanol / 12 h / 25 °C

6: H₂ / Pd/C / ethanol / 6 h / 25 °C

With hydrogenchloride; n-butyllithium; hydrogen; lithium tri-t-butoxyaluminum hydride; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; 1: Vilsmeier-Haack formylation / 4: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.097