cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

Base Information

Chemical Name:cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate
CAS No.:1018674-33-3
Molecular Formula:C₂₉H₄₂N₂O₆
Molecular Weight:514.662
Hs Code.:

Synonyms:cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

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Chemical Property of cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

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Technology Process of cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

There total 8 articles about cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 860216-27-9
O-(1-isobutoxyethyl)hydroxylamine

: 1018674-32-2
(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

: 1018674-33-3
cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

Guidance literature:: (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

O-(1-isobutoxyethyl)hydroxylamine; With triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1018674-33-3
cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water / 17 h / 0 - 20 °C

1.2: pH 1 / Acidic aqueous solution

2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 1 h / Heating / reflux

3.1: pyridine / dichloromethane / 18 h / 20 °C

4.1: pyridine; lithium iodide / 72 h / Heating / reflux

4.2: pH 1

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

5.2: 3.5 h / 20 °C

With pyridine; thionyl chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; lithium iodide; In dichloromethane; water; toluene;

Reference yield:

: 914604-31-2
(S)-tert-butoxycarbonylamino-cyclohexyl-acetic acid cyclopentyl ester

: 1018674-33-3
cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 24 h / 20 °C

2.1: pyridine / dichloromethane / 18 h / 20 °C

3.1: pyridine; lithium iodide / 72 h / Heating / reflux

3.2: pH 1

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

4.2: 3.5 h / 20 °C

With pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In 1,4-dioxane; dichloromethane;