(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Base Information

Chemical Name:(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid
CAS No.:1018674-32-2
Molecular Formula:C₂₃H₂₉NO₅
Molecular Weight:399.487
Hs Code.:

Synonyms:(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Suppliers and Price of (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

There total 8 articles about (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018674-31-1
methyl (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylate

: 1018674-32-2
(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Guidance literature:: methyl (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylate; With pyridine; lithium iodide; for 72h; Heating / reflux;

With hydrogenchloride; water; pH=1;

Reference yield:

: 914604-31-2
(S)-tert-butoxycarbonylamino-cyclohexyl-acetic acid cyclopentyl ester

: 1018674-32-2
(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 24 h / 20 °C

2.1: pyridine / dichloromethane / 18 h / 20 °C

3.1: pyridine; lithium iodide / 72 h / Heating / reflux

3.2: pH 1

With pyridine; hydrogenchloride; lithium iodide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1018674-32-2
(2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / water / 17 h / 0 - 20 °C

1.2: pH 1 / Acidic aqueous solution

2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 1 h / Heating / reflux

3.1: pyridine / dichloromethane / 18 h / 20 °C

4.1: pyridine; lithium iodide / 72 h / Heating / reflux

4.2: pH 1

With pyridine; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; lithium iodide; In dichloromethane; water; toluene;