allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

Base Information

Chemical Name:allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate
CAS No.:113599-68-1
Molecular Formula:C₃₈H₄₈N₂O₅Si
Molecular Weight:640.895
Hs Code.:

Synonyms:allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

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Technology Process of allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

There total 6 articles about allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-75-3
butyryl chloride

: 113599-63-6
allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-(tritylamino)-1-azetidinyl>acetate

: 113599-68-1
allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jm00401a020

Reference yield:

: 40630-84-0
allyl bromoacetate

: 113599-68-1
allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / tetrabutylammonium bromide, KOH / tetrahydrofuran / 20 h

2: 90 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With potassium hydroxide; tetrabutylammomium bromide; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm00401a020

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 113599-68-1
allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxohexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N, 4-(dimethylamino)pyridine, 2.) KF / 1.) DMF, 1 h, 2.) HOAc, 1 h

2: H₂ / 10percent Pd on charcoal / ethyl acetate / 3 h

3: NEt₃ / CH₂Cl₂ / 1.5 h

4: 59 percent / tetrabutylammonium bromide, KOH / tetrahydrofuran / 20 h

5: 90 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With dmap; potassium fluoride; potassium hydroxide; tetrabutylammomium bromide; hydrogen; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm00401a020