(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

Base Information

Chemical Name:(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane
CAS No.:760210-71-7
Molecular Formula:C₂₈H₄₀O₄Si
Molecular Weight:468.709
Hs Code.:

Synonyms:(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

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Chemical Property of (Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

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Technology Process of (Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

There total 5 articles about (Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 107-30-2
chloromethyl methyl ether

: 760210-70-6
(Z)-(1S,2S,4S)-1-(2-phenyl-[1,3]dioxan-4-yl)-7-triisopropylsilanyl-hept-4-en-2,6-diyn-1-ol

: 760210-71-7
(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 36h; Heating;
DOI:10.1021/ja047190o

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 760210-71-7
(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Pd(PPh₃)4; CuI; n-BuNH₂ / diethyl ether / 20 °C

2: 1.44 g / Pd(PPh₃)4; CuI; n-BuNH₂ / diethyl ether / 20 °C

3: K₂CO₃; methanol / benzene / 2 h / 20 °C

4: 77 percent / Zn(OTf)2; (+)-N-methylephedrine; Et₃N / toluene / 2 h / 20 °C

5: 86 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 36 h / 20 °C / Heating

With methanol; dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc trifluoromethanesulfonate; potassium carbonate; (+)-N-methylephedrine; N-butylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene; benzene; 1: Sonogashira coupling / 2: Sonogashira coupling;
DOI:10.1021/ja047190o

Reference yield:

: 149776-77-2
(Z)-(4-chlorobut-3-en-1-ynyl)triisopropylsilane

: 760210-71-7
(Z)-(1S,2S,4S)-triisopropyl-[7-methoxymethoxy-7-(2-phenyl-[1,3]dioxan-4-yl)hept-1,5-diynyl]silane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.44 g / Pd(PPh₃)4; CuI; n-BuNH₂ / diethyl ether / 20 °C

2: K₂CO₃; methanol / benzene / 2 h / 20 °C

3: 77 percent / Zn(OTf)2; (+)-N-methylephedrine; Et₃N / toluene / 2 h / 20 °C

4: 86 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 36 h / 20 °C / Heating

With methanol; dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc trifluoromethanesulfonate; potassium carbonate; (+)-N-methylephedrine; N-butylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene; benzene; 1: Sonogashira coupling;
DOI:10.1021/ja047190o