2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

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Chemical Name:2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester
CAS No.:250284-85-6
Molecular Formula:C₃₀H₃₁Br₂NO₇
Molecular Weight:677.387
Hs Code.:

Synonyms:2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

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Chemical Property of 2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

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Technology Process of 2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

There total 13 articles about 2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 250284-84-5
2-[(Z)-Benzyloxyimino]-3-{3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

: 250284-85-6
2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 50 ℃;
DOI:10.1016/S0040-4039(99)01429-X

Reference yield:

: 6793-92-6
p-benzyloxyphenylbromide

: 250284-85-6
2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 93 percent / Mg / tetrahydrofuran / Heating

2: 99 percent / K₂OsO₂(OH)2; K₂CO₃; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 20 °C

3: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C

4: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C

5: 87 percent / NBS / dimethylformamide / 20 °C

6: 76 percent / NaH / dimethylformamide / 90 °C

7: 95 percent / NaBH₄ / methanol; tetrahydrofuran / 20 °C

8: 90 percent / Ph₃P; I₂; imidazole / 20 °C

9: 85 percent / diethyl ether / 20 °C

10: 85 percent / BuONO; NaOMe / methanol / 0 °C

11: 87 percent / NaH / dimethylformamide / 20 °C

12: 85 percent / NBS / acetonitrile / 50 °C

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; K₂OsO₂(OH)2; hydrogen; iodine; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; magnesium; triphenylphosphine; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III); palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Alkylation / 2: Oxidation / 3: acetonization / 4: Reduction / 5: Bromination / 6: Arylation / 7: Reduction / 8: Iodination / 9: Substitution / 10: Nitrosation / 11: Alkylation / 12: Bromination;
DOI:10.1016/S0040-4039(99)01429-X

Reference yield:

: 90617-59-7
1-(benzyloxy)-4-(prop-2-en-1-yl)benzene

: 250284-85-6
2-[(Z)-Benzyloxyimino]-3-{3-bromo-5-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 99 percent / K₂OsO₂(OH)2; K₂CO₃; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 20 °C

2: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C

3: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C

4: 87 percent / NBS / dimethylformamide / 20 °C

5: 76 percent / NaH / dimethylformamide / 90 °C

6: 95 percent / NaBH₄ / methanol; tetrahydrofuran / 20 °C

7: 90 percent / Ph₃P; I₂; imidazole / 20 °C

8: 85 percent / diethyl ether / 20 °C

9: 85 percent / BuONO; NaOMe / methanol / 0 °C

10: 87 percent / NaH / dimethylformamide / 20 °C

11: 85 percent / NBS / acetonitrile / 50 °C

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; K₂OsO₂(OH)2; hydrogen; iodine; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triphenylphosphine; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III); palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Oxidation / 2: acetonization / 3: Reduction / 4: Bromination / 5: Arylation / 6: Reduction / 7: Iodination / 8: Substitution / 9: Nitrosation / 10: Alkylation / 11: Bromination;
DOI:10.1016/S0040-4039(99)01429-X