Technology Process of 2-[(Z)-Benzyloxyimino]-3-{3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester
There total 12 articles about 2-[(Z)-Benzyloxyimino]-3-{3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-4-methoxy-phenyl}-propionic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 93 percent / Mg / tetrahydrofuran / Heating
2: 99 percent / K2OsO2(OH)2; K2CO3; K3Fe(CN)6 / 2-methyl-propan-2-ol; H2O / 20 °C
3: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C
4: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C
5: 87 percent / NBS / dimethylformamide / 20 °C
6: 76 percent / NaH / dimethylformamide / 90 °C
7: 95 percent / NaBH4 / methanol; tetrahydrofuran / 20 °C
8: 90 percent / Ph3P; I2; imidazole / 20 °C
9: 85 percent / diethyl ether / 20 °C
10: 85 percent / BuONO; NaOMe / methanol / 0 °C
11: 87 percent / NaH / dimethylformamide / 20 °C
With
1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; K2OsO2(OH)2; hydrogen; iodine; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; magnesium; triphenylphosphine; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III);
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
1: Alkylation / 2: Oxidation / 3: acetonization / 4: Reduction / 5: Bromination / 6: Arylation / 7: Reduction / 8: Iodination / 9: Substitution / 10: Nitrosation / 11: Alkylation;
DOI:10.1016/S0040-4039(99)01429-X
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 99 percent / K2OsO2(OH)2; K2CO3; K3Fe(CN)6 / 2-methyl-propan-2-ol; H2O / 20 °C
2: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C
3: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C
4: 87 percent / NBS / dimethylformamide / 20 °C
5: 76 percent / NaH / dimethylformamide / 90 °C
6: 95 percent / NaBH4 / methanol; tetrahydrofuran / 20 °C
7: 90 percent / Ph3P; I2; imidazole / 20 °C
8: 85 percent / diethyl ether / 20 °C
9: 85 percent / BuONO; NaOMe / methanol / 0 °C
10: 87 percent / NaH / dimethylformamide / 20 °C
With
1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; K2OsO2(OH)2; hydrogen; iodine; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triphenylphosphine; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III);
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
1: Oxidation / 2: acetonization / 3: Reduction / 4: Bromination / 5: Arylation / 6: Reduction / 7: Iodination / 8: Substitution / 9: Nitrosation / 10: Alkylation;
DOI:10.1016/S0040-4039(99)01429-X
