(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

Base Information

Chemical Name:(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone
CAS No.:1442430-94-5
Molecular Formula:C₂₂H₃₄BNO₃
Molecular Weight:371.328
Hs Code.:

Synonyms:(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

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Chemical Property of (2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

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Technology Process of (2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

There total 6 articles about (2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1442430-93-4
(2-(tert-butyl)-4-chlorophenyl)(piperidin-1-yl)methanone

: 73183-34-3
bis(pinacol)diborane

: 1442430-94-5
(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

Guidance literature:: With potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 90 ℃; for 3h;

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 1442430-94-5
(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 48 h / 20 °C

2: pyridine / dichloromethane / 4 h / 0 - 20 °C

3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 55 °C

4: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 85 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

6: potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 3 h / 90 °C

With pyridine; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; water; potassium acetate; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 13395-85-2
2-(tert-butyl)-4-chlorophenol

: 1442430-94-5
(2-(tert-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 4 h / 0 - 20 °C

2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 55 °C

3: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 85 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

5: potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 3 h / 90 °C

With pyridine; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; water; potassium acetate; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;