tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

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Chemical Name:tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate
CAS No.:1236189-56-2
Molecular Formula:C₂₉H₃₀N₄O₄
Molecular Weight:498.582
Hs Code.:

Synonyms:tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

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Chemical Property of tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

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Technology Process of tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

There total 9 articles about tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236144-54-9,1236148-77-8
(Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate

: 1236188-99-0
4-cyclopropyl-5-phenylisoxazole-3-carboxylic acid

: 1236189-56-2
tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 1236144-51-6
O₁-benzyl-O₃-tert-butylazetidine-1,3-dicarboxylate

: 1236189-56-2
tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2250.23 Torr / Autoclave

2: sodium cyanoborohydride / methanol / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 20 °C / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C / Inert atmosphere

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.6b00089

Reference yield:

: 1236144-52-7
tert-butyl azetidine-3-carboxylate acetic acid salt

: 1236189-56-2
tert-butyl 1-(4-(5-(4-cyclopropyl-5-phenylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride / methanol / 0 - 20 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 20 °C / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium cyanoborohydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.6b00089