6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

Base Information

Chemical Name:6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine
CAS No.:1440958-05-3
Molecular Formula:C₂₁H₁₄ClN₃S
Molecular Weight:375.881
Hs Code.:

Synonyms:6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

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Chemical Property of 6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

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Technology Process of 6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

There total 10 articles about 6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1440958-03-1
6-(1-benzyl-1H-indol-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one

: 1440958-05-3
6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 0 - 50 ℃;
DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

: 703-80-0
3-acetylindole

: 1440958-05-3
6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: 0.08 h / 20 °C

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

2.3: Cooling with ice

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

4.1: di-2-pyridyl thionocarbonate; dmap / dichloromethane / 20 °C

5.1: sodium sulfide nonahydrate / N,N-dimethyl-formamide / 2 h / 50 °C

6.1: N,N-dimethyl-formamide / 2 h / 50 °C

7.1: sodium ethanolate / ethanol / 2 h / 50 °C

8.1: sulfuric acid / 24.5 h / 0 - 40 °C

9.1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 50 °C

With dmap; sulfuric acid; sodium sulfide nonahydrate; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; di-2-pyridyl thionocarbonate; potassium hydroxide; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

: 93315-38-9
3-acetyl-1-benzyl-1H-indole

: 1440958-05-3
6-(1-benzyl-1H-indol-3-yl)-4-chlorothieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 0.5 h / 0 °C

1.2: 3 h / 0 - 20 °C

1.3: Cooling with ice

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

3.1: di-2-pyridyl thionocarbonate; dmap / dichloromethane / 20 °C

4.1: sodium sulfide nonahydrate / N,N-dimethyl-formamide / 2 h / 50 °C

5.1: N,N-dimethyl-formamide / 2 h / 50 °C

6.1: sodium ethanolate / ethanol / 2 h / 50 °C

7.1: sulfuric acid / 24.5 h / 0 - 40 °C

8.1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 50 °C

With dmap; sulfuric acid; sodium sulfide nonahydrate; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; di-2-pyridyl thionocarbonate; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: |Vilsmeier-Haack Formylation / 1.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.03.022