<4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Base Information

Chemical Name:<4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine
CAS No.:109553-29-9
Molecular Formula:C₃₂H₄₇F₂N₅O₅
Molecular Weight:619.752
Hs Code.:

Synonyms:<4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

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Chemical Property of <4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

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Technology Process of <4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

There total 10 articles about <4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 97920-16-6
N-L-isoleucyl-2-pyridylmethylamine

: 109553-28-8
sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoate

: 109553-29-9
<4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 18h;
DOI:10.1021/jm00393a026

Reference yield:

: 104-94-9
4-methoxy-aniline

: 109553-29-9
[(S)-1-((R)-2,2-Difluoro-1-(4-methoxy-phenylamino)-2-{(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 15 h / Ambient temperature

2: 92 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

3: 1M aq. NaOH / tetrahydrofuran / 20 h

4: 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 18 h

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00393a026

Reference yield:

: 104-94-9
4-methoxy-aniline

: 109553-29-9
<4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 15 h / Ambient temperature

2: 100 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

3: 1M aq. NaOH / tetrahydrofuran / 20 h

4: 100 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 18 h

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00393a026