(S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

Base Information

Chemical Name:(S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate
CAS No.:875574-96-2
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

Synonyms:(S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

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Chemical Property of (S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

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Technology Process of (S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

There total 2 articles about (S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824943-43-3
(S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester

: 875574-96-2
(S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Pd/C / ethyl acetate / 4 h / 20 °C

2: 4.0 g / BOP; DIPEA / CH₂Cl₂ / 0 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ol052598r

Reference yield:

: 875574-58-6
L-allysine ethylene acetal methyl ester

: 182422-50-0
(2S)-2-([(benzyloxy)carbonyl]amino)hex-5-enoic acid

: 875574-96-2
(S)-methyl 2-((R)-2-(benzyloxycarbonylamino)hex-5-enamido)-5-(1,3-dioxolan-2-yl)pentanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/ol052598r