2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

Base Information

Chemical Name:2-benzyl-2-methyl-4-phenylbut-3-ynenitrile
CAS No.:1426841-44-2
Molecular Formula:C₁₈H₁₅N
Molecular Weight:245.324
Hs Code.:

Synonyms:2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

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Chemical Property of 2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

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Technology Process of 2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

There total 3 articles about 2-benzyl-2-methyl-4-phenylbut-3-ynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1426841-51-1
potassium 2-cyano-2-methyl-3-phenylpropanoate

: 932-87-6
1-Bromo-2-phenylacetylene

: 1426841-44-2
2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

Guidance literature:: With 8-quinolinol; silver carbonate; copper(I) bromide; In N,N-dimethyl acetamide; at 130 ℃; for 16h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol400197y

Reference yield:

: 104876-35-9
ethyl 2-cyano-2-methyl-3-phenylpropanoate

: 1426841-44-2
2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / ethanol; water / 0.5 h / 60 °C / Schlenk technique; Inert atmosphere

2: copper(I) bromide; 8-quinolinol; silver carbonate / N,N-dimethyl acetamide / 16 h / 130 °C / Schlenk technique; Inert atmosphere

With 8-quinolinol; potassium tert-butylate; silver carbonate; copper(I) bromide; In ethanol; N,N-dimethyl acetamide; water;
DOI:10.1021/ol400197y

Reference yield:

: 536-74-3
phenylacetylene

: 1426841-44-2
2-benzyl-2-methyl-4-phenylbut-3-ynenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 5 h / 20 °C / Schlenk technique; Inert atmosphere

2: copper(I) bromide; 8-quinolinol; silver carbonate / N,N-dimethyl acetamide / 16 h / 130 °C / Schlenk technique; Inert atmosphere

With N-Bromosuccinimide; 8-quinolinol; silver nitrate; silver carbonate; copper(I) bromide; In N,N-dimethyl acetamide; acetone;
DOI:10.1021/ol400197y