104876-35-9Relevant academic research and scientific papers
AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
-
Paragraph 0188, (2021/08/05)
The present invention relates to new compounds that show pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the μ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
Preparation of W/O nanoemulsion using tandem acoustic emulsification and its novel utilization as a medium for phase-transfer catalytic reaction
Nakabayashi,Yanagi,Atobe
, p. 57608 - 57610 (2015/02/19)
We have successfully demonstrated that a W/O nanoemulsion prepared by the tandem acoustic emulsification is an extremely useful medium for enhancing the rate of phase-transfer catalytic reactions.
Catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates using a phase-transfer catalyst
Nagata, Kazuhiro,Sano, Daisuke,Shimizu, Yu,Miyazaki, Michiko,Kanemitsu, Takuya,Itoh, Takashi
scheme or table, p. 2530 - 2536 (2010/03/31)
The catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates with an alkyl halide was performed under phase-transfer conditions to afford compounds which have a chiral quaternary carbon with up to 97% and 94% ee, respectively. As applicati
A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST
-
Page/Page column 32; 81-82, (2008/06/13)
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c} separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.
The Synthetic Potential of the Isocyanide-Cyanide Rearrangement
Meier, Michael,Ruechardt, Christoph
, p. 1 - 4 (2007/10/02)
Excellent chemical and optical yields (>96percent retention) of cyanides are achieved by vapor phase thermolysis or short contact flow thermolysis of isocyanides. trans-2-Butenyl isocyanide rearranges without concomitant allylic isomerization to trans-2-butenyl cyanide.Optically active 1-(formyloxymethyl)-2-phenylethyl cyanide is obtained from optically active L-phenylalanine as a new type of chiral pool synthon.
