bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

Base Information

Chemical Name:bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate
CAS No.:1418756-37-2
Molecular Formula:C₁₇H₂₄NO₃P
Molecular Weight:321.356
Hs Code.:

Synonyms:bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

Suppliers and Price of bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

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Technology Process of bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

There total 2 articles about bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 622-97-9,24936-41-2
1-ethenyl-4-methylbenzene

: 1397230-15-7
bis(1-methylethyl) [cyano(diazo)methyl]phosphonate

: 1418756-37-2
bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

Guidance literature:: With C₃₂H₄₈N₄O₁₂Rh₂; In benzene; at 20 ℃; for 20h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ja3099728

Reference yield:

: 21658-95-7
diisopropyl (cyanomethyl)phosphonate

: 1418756-37-2
bis(1-methylethyl) [(1S,2R)-1-cyano-2-(4-methylphenyl)cyclopropyl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine; sodium azide / acetonitrile; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: C₃₂H₄₈N₄O₁₂Rh₂ / benzene / 20 h / 20 °C / Inert atmosphere

With sodium azide; 2-chloro-1,3-dimethyl imidazolium chloride; C₃₂H₄₈N₄O₁₂Rh₂; triethylamine; In tetrahydrofuran; acetonitrile; benzene;
DOI:10.1021/ja3099728