21658-95-7

Usage

Uses

Used in Pharmaceutical Industry:
Diisopropyl Cyanomethylphosphonate is used as a chemical reagent for the synthesis of elfamycin intermediates, which are important building blocks in the production of various antibiotics, such as erythromycin and oleandomycin. These antibiotics are widely used to treat bacterial infections in humans and animals.
Used in Chemical Research:
DFP is also utilized in chemical research for studying the mechanism of action of organophosphorus compounds on acetylcholinesterase inhibition. This research helps in understanding the toxic effects of nerve agents and the development of potential antidotes or therapeutic agents for nerve agent exposure.

InChI:InChI=1/C8H16NO3P/c1-7(2)11-13(10,6-5-9)12-8(3)4/h7-8H,6H2,1-4H3

Upstream product

• 116-17-6 triisopropyl phosphite 
• 107-14-2 chloroacetonitrile 
• 35717-98-7 bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate 
• 143-33-9 sodium cyanide 
• 590-17-0 cyanomethyl bromide 
• 24630-68-0 diisopropyl hydroxymethylphosphonate 
• 1809-20-7 diisopropyl hydrogenphosphonate 

Downstream Products

• 20638-88-4 retinonitrile 
• 118559-11-8 (E)-4-[Bis-(4-fluoro-phenyl)-methylene]-5-methyl-hex-2-enenitrile 
• 99302-44-0 C₁₉⁽¹³⁾CH₂₇N 
• 99302-45-1 C₁₉⁽¹³⁾CH₂₇N 
• 105191-69-3 (9E)-(6-13C)-β-ionylideneacetonitrile 
• 105176-06-5 (9E)-(5-13C)-β-ionnylideneacetonitrile 
• 105176-07-6 (9E)-(7-13C)-β-ionylideneacetonitrile 
• 105176-08-7 (9E)-(5-13CH3)-β-ionnylideneacetonitrile 
• 175551-70-9 (S,2E,4E)-8-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-4-methylocta-2,4-dienenitrile 
• 1042979-11-2 [3-((E)-2-{4-[Bis-(4-methoxy-phenyl)-amino]-phenyl}-vinyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile 

Relevant academic research and scientific papers

Total Synthesis of Biselyngbyolide B

The first total synthesis of biselyngbyolide B, an 18-membered macrolide, was achieved. The 18-membered ring structure was constructed by esterification using the Shiina reagent and an intramolecular Stille coupling reaction.

Metal Oxide Nanoparticles Coated With Specific N-Acylaminomethylene Phosphonates

The present invention relates to new metal oxide nanoparticles coated with specific phosphonates, to the use of these nanoparticles as antimicrobials, especially in the home and personal care areas, to the production of such nanoparticles as well as to the new phosphonates and the corresponding process of production.

Biosynthesis of Naturally Products with a P-C Bond. Part 6. Preparation of Deuterium- and Carbon-13-Labelled L-Alanyl- and L-Alanyl-L-alanyl-(2-aminoethyl)phosphonic Acids and their Use in Biosynthetic Studies of Fosfomycin in Streptomyces fradiae

(2-Aminoethyl)phosphonic acid (AEP) is not taken up by Streptomyces fradiae in the biosynthesis of fosfomycin.Attachment of L-alanine or L-alanyl-L-alanine to the amino group of deuteriated AEP affords di- and tri-peptides 4 and 5 which are transported into the cell. AEP is synthesized from Na(13)CN and the tosyloxymethylphosphonate 7.It is transformed into dipeptide 4d, which acts as a carrier for AEP which is incorporated into fosfomycin with an enrichment of 2 percent.