Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-

Base Information

Chemical Name:Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-
CAS No.:130260-03-6
Molecular Formula:C₂₁H₂₇N₃O₂
Molecular Weight:353.464
Hs Code.:
DSSTox Substance ID:DTXSID90156424
Wikidata:Q83024488

Synonyms:BRN 4298347;Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-;130260-03-6;N-(1-Benzyl-4-piperidinyl)-2-methoxy-5-(methylamino)benzamide;2-Methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)benzamide;N-(1-benzylpiperidin-4-yl)-2-methoxy-5-(methylamino)benzamide;DTXSID90156424;SCVGNCAZSKGECY-UHFFFAOYSA-N;LS-27105;AE-641/30152052

Suppliers and Price of Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-

Chemical Property:

Vapor Pressure:6.21E-11mmHg at 25°C
Boiling Point:520.5°C at 760 mmHg
Flash Point:268.6°C
Density:1.16g/cm³
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:353.21032711
Heavy Atom Count:26
Complexity:431

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=CC(=C(C=C1)OC)C(=O)NC2CCN(CC2)CC3=CC=CC=C3

Technology Process of Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)-

There total 7 articles about Benzamide, 2-methoxy-5-(methylamino)-N-(1-(phenylmethyl)-4-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 130260-03-6
N-(1-benzyl-4-piperidinyl)-2-methoxy-5-(methylamino)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: formic acid / 1.) 100 - 125 deg C, 30 min, 2.) 170 deg C, 5 h

2: 97 percent / KOH / ethanol / 4 h / Heating

3: 100 percent / CHCl₃ / 1.5 h / Heating

4: 76 percent / N₂H₄*H₂O, Raney Ni / ethanol / 1.5 h / 60 °C

5: 96 percent / NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

6: 77 percent / tetrabutylamonium hydrogen sulfate, KOH / CH₂Cl₂; H₂O / 1 h / Ambient temperature

7: 77 percent / 90percent H₂SO₄ / diethyl ether / 1 h / 70 - 80 °C

With potassium hydroxide; formic acid; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; nickel; sodium hydrogencarbonate; hydrazine hydrate; In diethyl ether; ethanol; dichloromethane; chloroform; water;

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 130260-03-6
N-(1-benzyl-4-piperidinyl)-2-methoxy-5-(methylamino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / CHCl₃ / 1.5 h / Heating

2: 76 percent / N₂H₄*H₂O, Raney Ni / ethanol / 1.5 h / 60 °C

3: 96 percent / NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

4: 77 percent / tetrabutylamonium hydrogen sulfate, KOH / CH₂Cl₂; H₂O / 1 h / Ambient temperature

5: 77 percent / 90percent H₂SO₄ / diethyl ether / 1 h / 70 - 80 °C

With potassium hydroxide; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; nickel; sodium hydrogencarbonate; hydrazine hydrate; In diethyl ether; ethanol; dichloromethane; chloroform; water;

Reference yield:

: 90763-46-5
2-methoxy-5-nitrobenzoyl chloride

: 130260-03-6
N-(1-benzyl-4-piperidinyl)-2-methoxy-5-(methylamino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / CHCl₃ / 1.5 h / Heating

2: 76 percent / N₂H₄*H₂O, Raney Ni / ethanol / 1.5 h / 60 °C

3: 96 percent / NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

4: 77 percent / tetrabutylamonium hydrogen sulfate, KOH / CH₂Cl₂; H₂O / 1 h / Ambient temperature

5: 77 percent / 90percent H₂SO₄ / diethyl ether / 1 h / 70 - 80 °C

With potassium hydroxide; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; nickel; sodium hydrogencarbonate; hydrazine hydrate; In diethyl ether; ethanol; dichloromethane; chloroform; water;