(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester
CAS No.:807617-33-0
Molecular Formula:C₂₆H₄₀O₆Si
Molecular Weight:476.686
Hs Code.:

Synonyms:(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Suppliers and Price of (E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

There total 8 articles about (E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 807617-32-9
(E)-4-((4aR,6S,7R,8aS)-7-Hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-2-methyl-but-2-enoic acid ethyl ester

: 807617-33-0
(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/ja0449269

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 807617-33-0
(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 170 mg / CSA / ethyl acetate / 16 h / 20 °C

2: 173 mg / N-methylmorpholine / CH₂Cl₂ / 4 h / 20 °C

3: 98 percent / NaHCO₃; MeI / acetonitrile / 22 h / 20 °C

4: 95 percent / SmI₂ / tetrahydrofuran; methanol / 0.17 h / 0 °C

5: DIBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

6: 3.19 g / toluene / 0.5 h / 100 °C

7: 4.47 g / imidazole / dimethylformamide / 15 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; samarium diiodide; camphor-10-sulfonic acid; diisobutylaluminium hydride; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 2: hetero-Michael reaction / 6: Wittig reaction;
DOI:10.1021/ja0449269

Reference yield:

: 50907-65-8
2-deoxy-D-erythro-pentose cyclic 1,3-propanediyl mercaptal

: 807617-33-0
(E)-4-[(4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 170 mg / CSA / ethyl acetate / 16 h / 20 °C

2: 173 mg / N-methylmorpholine / CH₂Cl₂ / 4 h / 20 °C

3: 98 percent / NaHCO₃; MeI / acetonitrile / 22 h / 20 °C

4: 95 percent / SmI₂ / tetrahydrofuran; methanol / 0.17 h / 0 °C

5: DIBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

6: 3.19 g / toluene / 0.5 h / 100 °C

7: 4.47 g / imidazole / dimethylformamide / 15 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; samarium diiodide; camphor-10-sulfonic acid; diisobutylaluminium hydride; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 2: hetero-Michael reaction / 6: Wittig reaction;
DOI:10.1021/ja0449269