N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester

Base Information

• Chemical Name: N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester
• CAS No.: 1427268-50-5
• Molecular Formula: C₂₉H₄₄N₄O₈S
• Molecular Weight: 608.756
• Mol file: 1427268-50-5.mol

Synonyms:N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester

Chemical Property of N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester

There total 3 articles about N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)terephthalamic acid methyl ester (1427268-49-2) + biotin (58-85-5,22879-79-4) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester (1427268-50-5)

Guidance literature:

biotin; With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)terephthalamic acid methyl ester; In N,N-dimethyl-formamide; for 3h; Inert atmosphere;

DOI:10.3390/molecules171214174

Reference yield:

Monomethyl terephthalate (1679-64-7) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester (1427268-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules171214174

Reference yield:

4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester (1427268-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules171214174

upstream raw materials:

Monomethyl terephthalate

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)terephthalamic acid methyl ester

biotin

4,7,10-trioxa-1,13-diaminotridecane

Downstream raw materials:

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide