N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide

Base Information

• Chemical Name: N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide
• CAS No.: 1427268-51-6
• Molecular Formula: C₃₈H₆₄N₆O₁₀S
• Molecular Weight: 797.026
• Mol file: 1427268-51-6.mol

Synonyms:

Chemical Property of N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide

There total 4 articles about N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) + N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester (1427268-50-5) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide (1427268-51-6)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.3390/molecules171214174

Reference yield:

4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide (1427268-51-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

3.1: N,N-dimethyl-formamide

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules171214174

Reference yield:

Monomethyl terephthalate (1679-64-7) → N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-(3-(2-[2-(3-[biotin]propoxy)ethoxy]ethoxy)propyl)terephthalamide (1427268-51-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

3.1: N,N-dimethyl-formamide

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules171214174

upstream raw materials:

Monomethyl terephthalate

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)terephthalamic acid methyl ester

4,7,10-trioxa-1,13-diaminotridecane

N-(3-(2-[2-(3-aminopropoxy)ethoxy]ethoxy)propyl)-N'-biotinterephthalamic acid methyl ester