3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

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Chemical Name:3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile
CAS No.:1006599-04-7
Molecular Formula:C₃₁H₃₇F₃N₆O₂S
Molecular Weight:614.735
Hs Code.:

3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

Synonyms:3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

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Chemical Property of 3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

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Technology Process of 3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

There total 9 articles about 3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 669080-79-9
3-bromomethyl-5-trifluoromethyl-benzonitrile

: 1006599-60-5
N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

: 1006599-04-7
3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 0.5h; Cooling with ice;

3-bromomethyl-5-trifluoromethyl-benzonitrile; In N,N-dimethyl-formamide; at -78 - 20 ℃; for 12h;

Reference yield:

: 623942-84-7
2-(hydroxymethyl)-3-bromo-6-methoxypyridine

: 1006599-04-7
3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 0.05 h / 135 °C / Microwave irradiation (500 W)

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 19 h / 50 °C

5.1: manganese(IV) oxide / chloroform / 22 h / 55 °C

6.1: 1,2-dichloro-ethane / 0.17 h / 20 °C

6.2: 12 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C / Cooling with ice

7.2: 12 h / -78 - 20 °C

With hydrogenchloride; manganese(IV) oxide; water; sodium tris(acetoxy)borohydride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1006599-55-8
3-bromo-6-methoxy-2-((methoxymethoxy)methyl)pyridine

: 1006599-04-7
3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos / tetrahydrofuran / 0.05 h / 135 °C / Microwave irradiation (500 W)

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 19 h / 50 °C

4.1: manganese(IV) oxide / chloroform / 22 h / 55 °C

5.1: 1,2-dichloro-ethane / 0.17 h / 20 °C

5.2: 12 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C / Cooling with ice

6.2: 12 h / -78 - 20 °C

With hydrogenchloride; manganese(IV) oxide; water; sodium tris(acetoxy)borohydride; sodium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; 1,4-dioxane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;