2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine

Base Information

• Chemical Name: 2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine
• CAS No.: 1006599-54-7
• Molecular Formula: C7H11N3OS
• Molecular Weight: 185.25
• Mol file: 1006599-54-7.mol

Synonyms:2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine

Chemical Property of 2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine

Chemical Property:

• Boiling Point: 404.4±51.0 °C(Predicted)
• PKA: 3.44±0.10(Predicted)
• PSA: 86.33000
• Density: 1.242±0.06 g/cm3(Predicted)
• LogP: 1.38180
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

>97% ^*data from raw suppliers

5-(2-(Methylthio)ethoxy)pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine

There total 3 articles about 2-aMino-5-(2-(Methylthio)ethoxy)pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}hexanamide (1057667-17-0) → 2-amino-5-[2-(methylthio)ethoxy]pyrimidine (1006599-54-7)

Guidance literature:

With methanol; sodium methylate; at 60 ℃; for 2h; Product distribution / selectivity;

Reference yield:

N-(4-methoxybenzyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine (1006599-53-6) → 2-amino-5-[2-(methylthio)ethoxy]pyrimidine (1006599-54-7)

Guidance literature:

With trifluoroacetic acid; at 60 ℃; for 2.5h;

Reference yield:

sulfure de methyle et de 2-chloroethyle (542-81-4) + N-(5-hydroxypyrimidin-2-yl)hexanamide (1057667-15-8) → 2-amino-5-[2-(methylthio)ethoxy]pyrimidine (1006599-54-7)

Guidance literature:

sulfure de methyle et de 2-chloroethyle; N-(5-hydroxypyrimidin-2-yl)hexanamide; With sodium hydroxide; In isopropyl alcohol; at 90 ℃; for 3h;

With sodium hydroxide; In methanol; isopropyl alcohol; at 70 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

N-(4-methoxybenzyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

N-{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}hexanamide

sulfure de methyle et de 2-chloroethyle

N-(5-hydroxypyrimidin-2-yl)hexanamide

Downstream raw materials:

3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

3-{1-[({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl){5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino]methyl}-5-(trifluoromethyl)benzonitrile

N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({3-[(cyclopentylmethyl)(ethyl)amino]-6-methoxypyridin-2-yl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

Refernces

• 1、 -. "Novel pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same". Page/Page column 12. . Retrieved 2009/04/24.
• 2、 -. "NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME". Page/Page column 21. . Retrieved 2009/04/24.