2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester

Base Information

• Chemical Name: 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester
• CAS No.: 454465-87-3
• Molecular Formula: C₂₄H₂₃N₃O₆
• Molecular Weight: 449.463

Synonyms:2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester

Chemical Property of 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester

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Technology Process of 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester

There total 1 articles about 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde (148747-58-4) → 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester (454465-87-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 144h;

DOI:10.1021/jm020104f

Reference yield: 65.0%

acetic acid (64-19-7,77671-22-8) + 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester (454465-87-3) → 2-acetoxymethyl-4-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-but-2-enoic acid methyl ester (454465-79-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

DOI:10.1021/jm020104f

Reference yield: 62.0%

benzoic acid (65-85-0,8013-63-6) + 2-[2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-1-hydroxyethyl]acrylic acid methyl ester (454465-87-3) → benzoic acid 4-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-2-methoxycarbonyl-but-2-enyl ester

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

DOI:10.1021/jm020104f

upstream raw materials:

acrylic acid methyl ester

[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde

Downstream raw materials:

2-acetoxymethyl-4-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-but-2-enoic acid methyl ester

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