Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate

Base Information

Chemical Name:Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate
CAS No.:148747-58-4
Molecular Formula:C20H17 N3 O4
Molecular Weight:363.373
Hs Code.:
DSSTox Substance ID:DTXSID20438740
Wikidata:Q82254562

Synonyms:148747-58-4;Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate;Benzyl [6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl]carbamate;SCHEMBL6085892;DTXSID20438740;YHBUHBUMVBCLKV-UHFFFAOYSA-N;FT-0721796;[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1 pyrimidinyl]acetaldehyde;[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde

Suppliers and Price of Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:363.12190603
Heavy Atom Count:27
Complexity:617

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)NC2=CN=C(N(C2=O)CC=O)C3=CC=CC=C3

Technology Process of Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate

There total 12 articles about Benzyl (6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydropyrimidin-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 293329-60-9
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

: 148747-58-4
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 8h; Heating;
DOI:10.1021/jm00001a015

Reference yield:

: 148747-57-3
1-Allyl-5-benzyloxycarbonylamino-2-phenylpyrimid-6-(1H)-one

: 7529-22-8
4-methylmorpholine N-oxide

: 148747-58-4
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde

Guidance literature:: With hydrogenchloride; sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; ethanol; water; ethyl acetate;

Reference yield:

: 293329-57-4
1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-ylcarboxylic acid

: 148747-58-4
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 1 h / 0 °C

2: aq. hydroxylamine / tetrahydrofuran / 0.33 h / 0 °C

3: pyridine / tetrahydrofuran / 0.33 h / 20 °C

4: 1,8-diazabicyclo[5.4.0]-7-undecene / tetrahydrofuran; H₂O / 1 h / Heating

5: NaHCO₃ / tetrahydrofuran; H₂O / 0 °C

6: aq. HCl / acetic acid / 2 h / 70 °C

With pyridine; hydrogenchloride; hydroxylamine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; water; acetic acid; 4: Lossen rearrangement;
DOI:10.1055/s-2001-10786