Quinacrine ethyl mustard

Base Information

• Chemical Name: Quinacrine ethyl mustard
• CAS No.: 10072-25-0
• Molecular Formula: C₂₀H₂₂Cl₃N₃O*2ClH
• Molecular Weight: 499.695
• Mol file: 10072-25-0.mol

Synonyms:Quinacrine ethyl mustard;ICR-48b;NSC 34372;NSC-34372;9-(2-(Di(2-chloroethyl)amino)ethylamino)-6-chloro-2-methoxyacridine;Acridine, 9-(2-(bis(2-chloroethyl)amino)ethylamino)-6-chloro-2-methoxy-, dihydrochloride, hydrate;C20H22Cl3N3O.2ClH;Acridine, 9-((2-(bis(2-chloroethyl)amino)ethyl)amino)-6-chloro-2-methoxy-, dihydrochloride;C20-H22-Cl3-N3-O.2Cl-H.H2-O;Acridine, 9-[[2-[bis(2-chloroethyl)amino]ethyl]amino]-6-chloro-2-methoxy-, dihydrochloride;9-(2-(Di(2-chloroethyl)amino)ethylamino)-6-chloro-2-methoxy-acridine

Chemical Property of Quinacrine ethyl mustard

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 499.033251
• Heavy Atom Count: 29
• Complexity: 439

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)[NH2+]CC[NH+](CCCl)CCCl.[Cl-].[Cl-]

Technology Process of Quinacrine ethyl mustard

There total 3 articles about Quinacrine ethyl mustard which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-bis-(2-hydroxy-ethyl)-ethylenediamine (103509-15-5) → N,N-bis-(2-chloro-ethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-ethylenediamine; dihydrochloride (10072-25-0)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01524a041

Reference yield:

N,N-bis(2-hydroxyethyl)ethylidenediamine (3197-06-6) → N,N-bis-(2-chloro-ethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-ethylenediamine; dihydrochloride (10072-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: phenol / 110 °C

2: thionyl chloride

With thionyl chloride; phenol;

DOI:10.1021/ja01524a041

Reference yield:

6,9-dichloro-2-methoxyacridine (86-38-4) → N,N-bis-(2-chloro-ethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-ethylenediamine; dihydrochloride (10072-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: phenol / 110 °C

2: thionyl chloride

With thionyl chloride; phenol;

DOI:10.1021/ja01524a041

upstream raw materials:

N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-bis-(2-hydroxy-ethyl)-ethylenediamine

N,N-bis(2-hydroxyethyl)ethylidenediamine

6,9-dichloro-2-methoxyacridine