N,N-Bis(2-hydroxyethyl)ethylenediamine

Base Information

• Chemical Name: N,N-Bis(2-hydroxyethyl)ethylenediamine
• CAS No.: 3197-06-6
• Molecular Formula: C6H16N2O2
• Molecular Weight: 148.205
• Hs Code.: 2922199090
• European Community (EC) Number: 626-584-2
• NSC Number: 29614
• DSSTox Substance ID: DTXSID10185796
• Nikkaji Number: J388.262D
• Wikidata: Q72445957
• Mol file: 3197-06-6.mol

Synonyms:N,N-Bis(2-hydroxyethyl)ethylenediamine;3197-06-6;2,2'-((2-Aminoethyl)azanediyl)diethanol;2-[2-aminoethyl(2-hydroxyethyl)amino]ethanol;2,2'-((2-Aminoethyl)imino)bisethanol;Ethanol, 2,2'-((2-aminoethyl)imino)bis-;NSC29614;SCHEMBL62067;n-(2-aminoethyl)diethanolamine;DTXSID10185796;AC-128;MFCD00014822;NSC 29614;NSC-29614;AKOS009157443;2,2'-(2-aminoethylazanediyl)diethanol;SB84227;LS-185338;N,N-bis(2-hydroxyethyl)-1,2-ethanediamine;N,N-bis-(2-hydroxyethyl)-1,2-ethanediamine;2-[2-azanylethyl(2-hydroxyethyl)amino]ethanol;2-[(2-aminoethyl)(2-hydroxyethyl)amino]ethanol;2-[(2-aminoethyl)-(2-hydroxyethyl)amino]ethanol;A821082;J-018581

Chemical Property of N,N-Bis(2-hydroxyethyl)ethylenediamine

Chemical Property:

• Vapor Pressure: 0.000206mmHg at 25°C
• Melting Point: 92 °C
• Refractive Index: n20/D 1.498(lit.)
• Boiling Point: 291.7 °C at 760 mmHg
• PKA: 14.38±0.10(Predicted)
• Flash Point: 130.2 °C
• PSA: 69.72000
• Density: 1.069
• LogP: -1.06800
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water.
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 148.121177757
• Heavy Atom Count: 10
• Complexity: 64.8

Purity/Quality:

99%, ^*data from raw suppliers

N,N′-Bis(2-hydroxyethyl)ethylenediamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-37
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN(CCO)CCO)N

Technology Process of N,N-Bis(2-hydroxyethyl)ethylenediamine

There total 7 articles about N,N-Bis(2-hydroxyethyl)ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(2phthalimidoethyl)diethanolamine (118839-29-5) → N,N-bis(2-hydroxyethyl)ethylidenediamine (3197-06-6)

Guidance literature:

With hydrazine hydrate; In methanol; for 2.5h; Heating;

DOI:10.1016/S0968-0896(03)00273-6

Reference yield: 37.0%

2-(bis(2-hydroxyethyl)amino)acetonitrile (86241-19-2) → N,N-bis(2-hydroxyethyl)ethylidenediamine (3197-06-6)

Guidance literature:

2-(bis(2-hydroxyethyl)amino)acetonitrile; With C₄₆H₁₇₈O₄₁Si₄₂; titanium(IV)isopropoxide; In toluene; at 60 ℃; for 24h; Inert atmosphere;

With water; sodium hydroxide; In toluene; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2013.11.101

Reference yield:

triethanolamine (102-71-6,64114-46-1) → 1-(2-hydroxyethyl)piperazine (103-76-4) + N,N-bis(2-hydroxyethyl)ethylidenediamine (3197-06-6)

Guidance literature:

With ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20); at 165 ℃; for 4h; under 85781.4 - 99537.9 Torr; Product distribution / selectivity; Autoclave;

upstream raw materials:

oxirane

monoacetylaminoethylamine

ethylenediamine

2,2'-iminobis[ethanol]

Downstream raw materials:

N,N-bis-(2-hydroxy-ethyl)-N'-(2-phenyl-[4]quinolyl)-ethylenediamine

N,N-bis(2-chloroethyl)ethylenediamine dihydrochloride

N-<2--aethyl>-6-nitro-3,4-dimethyl-anilin

2-(2-Aminoethylamino)ethanol

Refernces

• 1、 -. "METHODS OF MAKING CYCLIC, N-AMINO FUNCTIONAL TRIAMINES". Page/Page column 30-31. . Retrieved 2010/04/28.
• 2、 Kohn, Kurt W.,Orr, Ann,O'Connor, Patrick M.,Guziec, Lynn James,Guziec, Frank S.. "Synthesis and DNA-Sequence Selectivity of a Series of Mono- and Difunctional 9-Aminoacridine Nitrogen Mustards". . p. 67 - 72. Retrieved 2007/10/02.