Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate

Base Information

• Chemical Name: Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate
• CAS No.: 74225-93-7
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.293
• DSSTox Substance ID: DTXSID101230649
• Mol file: 74225-93-7.mol

Synonyms:Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate;SCHEMBL10948212;DTXSID101230649;74225-93-7

Chemical Property of Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 260.11609238
• Heavy Atom Count: 19
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=CC=C1CN2C=CN=C2

Technology Process of Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate

There total 2 articles about Ethyl 2-[2-(1H-imidazol-1-ylmethyl)phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromoacetate (105-36-2) + 2-(imidazol-1-yl)methylphenol (41833-14-1) → 2-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (74225-93-7)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield:

1H-imidazole (288-32-4) + ethyl 2-(2-(bromomethyl)phenoxy)acetate (74225-91-5) → 2-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (74225-93-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 90 deg C, 1 h, 2.) DMF, 90 deg C, 1 h;

DOI:10.1021/jm00142a005

Reference yield:

2-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (74225-93-7) → 2-(1-imidazolylmethyl)phenoxyacetic acid (75341-05-8)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1021/jm00142a005

upstream raw materials:

1H-imidazole

ethyl 2-(2-(bromomethyl)phenoxy)acetate

ethyl bromoacetate

2-(imidazol-1-yl)methylphenol

Downstream raw materials:

2-(1-imidazolylmethyl)phenoxyacetic acid