2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

Base Information

Chemical Name:2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one
CAS No.:1192712-77-8
Molecular Formula:C₁₉H₂₀O₃
Molecular Weight:296.366
Hs Code.:

Synonyms:2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

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Chemical Property of 2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

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Technology Process of 2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

There total 34 articles about 2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: (7R,E)-5,7-dihydroxy-1,7-diphenylhept-2-en-1-one

: 1192712-77-8
2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

: 2-((2S,4S,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1016/j.tet.2020.131625

Reference yield: 66.0%

: (7R,E)-5-hydroxy-1,7-diphenyl-7-((triethylsilyl)oxy)hept-2-en-1-one

: 1192712-77-8
2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

: 2-((2S,4S,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

Guidance literature:: With camphor-10-sulfonic acid; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2020.131625

Reference yield: 61.0%

: 124306-11-2
(Z)-trimethyl((1-phenylbuta-1,3-dien-1-yl)oxy)silane

: (R)-3-phenyl-3-((trimethylsilyl)oxy)propanal

: 1192712-77-8
2-((2S,4R,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

: 2-((2S,4S,6R)-4-hydroxy-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethan-1-one

Guidance literature:: (Z)-trimethyl((1-phenylbuta-1,3-dien-1-yl)oxy)silane; (R)-3-phenyl-3-((trimethylsilyl)oxy)propanal; With boron trifluoride diethyl etherate; In methanol; dichloromethane; at -78 ℃; for 0.166667h; Inert atmosphere;

With camphor-10-sulfonic acid; In methanol; dichloromethane; at -78 - 20 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2020.131625