6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

Base Information

Chemical Name:6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline
CAS No.:213541-06-1
Molecular Formula:C₂₅H₁₇F₂NO₂
Molecular Weight:401.412
Hs Code.:

Synonyms:6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

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Chemical Property of 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

Chemical Property:

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Technology Process of 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

There total 11 articles about 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 213541-03-8
2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-hydroxymethyl-6-fluoroquinoline

: 2-fluoro-6-(2'-fluoro-biphenyl-4-yl)-7,11-dihydro-8H-10-oxa-5-aza-cyclohepta[a]naphthalen-9-one

: 213541-06-1
6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

Guidance literature:: With trifluorormethanesulfonic acid; at 130 ℃; for 5h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: acetic acid 10-fluoro-3-(2-fluoro-phenyl)-5-oxo-6,7-dihydro-5H-13-aza-benzo[3,4]cyclohepta[1,2-b]naphthalen-8-ylmethyl ester

: 213541-06-1
6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 2h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 213541-06-1
6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline

Guidance literature:: Multi-step reaction with 9 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

4.1: SOCl₂; DMF / toluene / 2 h / 55 °C

4.2: 75 percent / NaBH₄ / tetrahydrofuran / 1.5 h / 20 °C

5.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 20 °C

6.1: 98 percent / conc. HCl / acetic acid / 2 h / 55 °C

7.1: 81 percent / TfOH / 2 h / 130 °C

8.1: acetic acid / 22 h / 110 °C

9.1: 323 mg / NaOH / methanol; H₂O / 2 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; aluminium trichloride; thionyl chloride; trifluorormethanesulfonic acid; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3