5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene

Base Information

• Chemical Name: 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene
• CAS No.: 792965-54-9
• Molecular Formula: C₂₅H₂₉ClO
• Molecular Weight: 380.958
• Mol file: 792965-54-9.mol

Synonyms:5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene

Chemical Property of 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene

There total 4 articles about 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5R/S)-10-[(1R)-menthyloxy]-5H-dibenzo[a,d]cyclohepten-5-ol (540512-18-3) → 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene (792965-54-9)

Guidance literature:

With thionyl chloride; In toluene; at -15 - 20 ℃;

DOI:10.1002/chem.200400441

Reference yield:

10-[(1R)-menthyloxy]-dibenzo[a,d]cyclohepten-5-one (540512-16-1) → 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene (792965-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / sodium borohydride; aq. sodium hydroxide / methanol / 3 h / 20 °C

2: thionyl chloride / toluene / -15 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; In methanol; toluene;

DOI:10.1002/chem.200400441

Reference yield:

10-bromo-5H-dibenzo[a,d]cyclohepten-5-one (17044-50-7) → 5-chloro-10-(2-isopropyl-5-methyl-cyclohexyloxy)-5H-dibenzo[a,d]cycloheptene (792965-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / dioxane / 3 h / 100 °C

2: 94 percent / sodium borohydride; aq. sodium hydroxide / methanol / 3 h / 20 °C

3: thionyl chloride / toluene / -15 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; In 1,4-dioxane; methanol; toluene;

DOI:10.1002/chem.200400441

upstream raw materials:

(5R/S)-10-[(1R)-menthyloxy]-5H-dibenzo[a,d]cyclohepten-5-ol

10-[(1R)-menthyloxy]-dibenzo[a,d]cyclohepten-5-one

10-bromo-5H-dibenzo[a,d]cyclohepten-5-one

potassium (-)-menthoxide