Tianeptine

Base Information

Chemical Name:Tianeptine
CAS No.:66981-73-5
Molecular Formula:C₂₁H₂₅ClN₂O₄S
Molecular Weight:436.96
Hs Code.:
Mol file:66981-73-5.mol

Synonyms:Heptanoicacid, 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]-,S,S-dioxide, (?à)-;Dibenzo[c,f][1,2]thiazepine, heptanoic acid deriv.;Coaxil;Tianeptine acid;

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Tianeptine

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:1.08E-15mmHg at 25°C
Melting Point:129-131 °C
Refractive Index:1.639
Boiling Point:609.2 °C at 760 mmHg
Flash Point:322.2 °C
PSA：95.09000
Density:1.38 g/cm³
LogP:5.72930
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Freely soluble in water, in methanol and in methylene chloride.

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Tianeptine is used in the treatment of reactive and neurotic depression, as well as in the treatment of anxious states. Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
Therapeutic Function Antidepressant

Technology Process of Tianeptine

There total 9 articles about Tianeptine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 66981-77-9
ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate

: 191172-75-5,169293-31-6,66981-73-5
tianeptine

Guidance literature:: With sodium hydroxide; In water; for 3h; Reflux;

Reference yield:

: 1231718-21-0
7-(((11RS)-3-chloro-6-methyl-6,11-dihydro-dibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanenitrile S,S-dioxide

: 191172-75-5,169293-31-6,66981-73-5
tianeptine

Guidance literature:: 7-(((11RS)-3-chloro-6-methyl-6,11-dihydro-dibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanenitrile S,S-dioxide; With hydrogenchloride; In water; Reflux;

With sodium hydroxide; In water; at 0 - 5 ℃; pH=~ 5.8 - 6.2;