66981-77-9

Basic information

• Product Name: Tianeptine Ethyl Ester
• Synonyms: Tianeptine Ethyl Ester;FEFUFMZSNHPQDX-UHFFFAOYSA-N
• CAS NO: 66981-77-9
• Molecular Formula: C23H29ClN2O4S
• Molecular Weight: 465.00536
• Mol File: 66981-77-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 573.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 7.44±0.20(Predicted)
• CAS DataBase Reference: Tianeptine Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tianeptine Ethyl Ester(66981-77-9)
• EPA Substance Registry System: Tianeptine Ethyl Ester(66981-77-9)

Safety Data

• Hazardous Substances Data: 66981-77-9(Hazardous Substances Data)

Usage

Uses

Tianeptine Ethyl Ester is an impurity of Tianeptine (T436800),an tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties.

Upstream product

• 26638-66-4 5,8-dichloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepine 
• 29840-65-1 7-aminoheptanoic acid ethyl ester hydrochloride 
• 26723-60-4 5-hydroxy-8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepine 
• 1117-66-4 7-aminoheptanoic acid ethyl ester 
• 26638-53-9 8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepin-5-one 
• 191172-75-5 tianeptine 
• 64-17-5 ethanol 

Relevant articles and documents

A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

The present invention relates to a method for preparing 3,11-dichloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide. More particularly, the present invention relates to a method for preparing high-purity 3,11-dichloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide at a high yield under safe atmosphere through a quantitative reaction without introduction of an excessive amount of hydrogen chloride gas from the outside by substituting the hydroxyl group of 3-chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine-11-ol 5,5-dioxide as a starting material with a chloride group by means of hydrogen chloride gas generated in situ under the environment of acetyl chloride and the same equivalent of alcohol.

Tianeptine esters derivatives: A study of protein-drug interaction performed by fluorescence quenching and molecular docking

The nature of binding between bovine serum albumin (BSA) and the antidepressant tianeptine and a new series of esters derivatives were studied in this paper. The interactions with BSA were investigated by UV-Vis and fluorescence spectroscopy at three different temperatures. The fluorescence quenching experiments showed that BSA interactions with tianeptine could be dynamic while to its esters a static mechanism was observed. The results showed that tianeptine quenches the intrinsic fluorescence of BSA more efficiently than its esters due to the presence of the free acid portion. The number of binding sites determined by fluorescence spectroscopy is approximately equal to 1 indicating that there is one binding site between BSA tianeptine esters, but the presence of a second interaction site for tianeptine at higher temperatures could be not ruled out. Molecular docking calculations point out a strong affinity of tianeptine and its esters to the site IIA of protein, supporting the hypothesis of a static quenching mechanism.