8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

Base Information

Chemical Name:8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline
CAS No.:1376918-84-1
Molecular Formula:C₂₅H₂₂N₄O
Molecular Weight:394.476
Hs Code.:

Synonyms:8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

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Chemical Property of 8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

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Technology Process of 8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

There total 15 articles about 8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₀N₄O

: 1376918-84-1
8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.03.077

Reference yield:

: C₁₈H₁₁ClN₄O₂

: 1376918-84-1
8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

Guidance literature:: Multi-step reaction with 7 steps

1: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

2: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere

3: sodium methylate / methanol / 2 h / Reflux; Inert atmosphere

4: sodium tetrahydroborate / methanol / 1 h / 0 °C / Reflux; Inert atmosphere

5: palladium 10% on activated carbon; hydrazine hydrate / methanol / 5 h / Reflux; Inert atmosphere

6: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere

7: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; palladium 10% on activated carbon; sodium methylate; sodium cyanoborohydride; hydrazine hydrate; acetic acid; In methanol; water;
DOI:10.1016/j.bmcl.2012.03.077

Reference yield:

: 1376918-13-6
8-amino-3-benzylamino-6-chloro-9H-β-carboline

: 1376918-84-1
8-methylamino-3-(3-phenoxybenzyl)amino-9H-β-carboline

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 2 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 0 °C / Reflux; Inert atmosphere

3: palladium 10% on activated carbon; hydrazine hydrate / methanol / 5 h / Reflux; Inert atmosphere

4: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere

5: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; sodium methylate; sodium cyanoborohydride; hydrazine hydrate; acetic acid; In methanol;
DOI:10.1016/j.bmcl.2012.03.077