Technology Process of 8-amino-3-benzylamino-6-chloro-9H-β-carboline
There total 7 articles about 8-amino-3-benzylamino-6-chloro-9H-β-carboline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: chloroform / 0.5 h / 40 °C / Inert atmosphere
2: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere
3: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere
4: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
5: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
6: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; sodium nitrate; tin(II) chloride dihdyrate; sodium cyanoborohydride; acetic acid; trifluoroacetic acid;
In
methanol; chloroform; water;
DOI:10.1016/j.bmcl.2012.03.077
- Guidance literature:
-
Multi-step reaction with 10 steps
1: N-chloro-succinimide / ethyl acetate / 18 h / Inert atmosphere; Reflux
2: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
3: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
4: acetic acid / water / 1 h / Reflux; Inert atmosphere
5: chloroform / 0.5 h / 40 °C / Inert atmosphere
6: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere
7: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere
8: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
9: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
10: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; sodium nitrate; N-chloro-succinimide; tin(II) chloride dihdyrate; sodium cyanoborohydride; hydrazine hydrate; acetic acid; trifluoroacetic acid; sodium nitrite;
In
methanol; pentan-1-ol; chloroform; water; ethyl acetate;
4: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.03.077
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere
3: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
4: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
5: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; sodium nitrate; tin(II) chloride dihdyrate; sodium cyanoborohydride; acetic acid; trifluoroacetic acid;
In
methanol; water;
DOI:10.1016/j.bmcl.2012.03.077
