3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester
CAS No.:649728-23-4
Molecular Formula:C₂₂H₂₉Cl₃N₂O₇
Molecular Weight:539.84
Hs Code.:

3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-<i>tert</i>-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Synonyms:3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Suppliers and Price of 3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

There total 7 articles about 3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 14529-00-1
benzyl 3-aminopropionate

: 649728-21-2
3-(tert-butoxycarbonyl-carboxymethylamino)-propionic acid 2,2,2-trichloroethylester

: 649728-23-4
3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1016/j.tetlet.2003.10.073

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 649728-23-4
3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂

2: 84 percent / H₂ / Pd/C / tetrahydrofuran

3: 82 percent / diethyl cyanophosphonate; Et₃N / dimethylformamide / 16 h / 25 °C

With diethyl cyanophosphonate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2003.10.073

Reference yield:

: 649728-15-4
β-alanine 2,2,2-trichloroethyl ester

: 649728-23-4
3-{[(2-benzyloxycarbonyl-ethylcarbamoyl)-methyl]-tert-butoxycarbonyl-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / Et₃N / CH₂Cl₂

2: 90 percent / DEAD; PPh₃ / CH₂Cl₂

3: 81 percent / PhSH; K₂CO₃ / dimethylformamide / 25 °C

4: 94 percent / Et₃N / CH₂Cl₂

5: 84 percent / H₂ / Pd/C / tetrahydrofuran

6: 82 percent / diethyl cyanophosphonate; Et₃N / dimethylformamide / 16 h / 25 °C

With diethyl cyanophosphonate; hydrogen; potassium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2003.10.073