14529-00-1

Basic information

• Product Name: BETA-ALANINE BENZYL ESTER
• Synonyms: BETA-ALANINE BENZYL ESTER;b-Alanine, phenylMethyl ester;3-Aminopropanoic acid benzyl ester
• CAS NO: 14529-00-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 14529-00-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BETA-ALANINE BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-ALANINE BENZYL ESTER(14529-00-1)
• EPA Substance Registry System: BETA-ALANINE BENZYL ESTER(14529-00-1)

Safety Data

• Hazardous Substances Data: 14529-00-1(Hazardous Substances Data)

Upstream product

• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 100-51-6 benzyl alcohol 
• 107-95-9 3-amino propanoic acid 
• 88574-54-3 benzyl 3-(tert-butyloxycarbonylamino)propionate 
• 63613-10-5 3-benzyloxycarbonylaminopropionic acid benzyl ester 

Downstream Products

• 138108-37-9 benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate 
• 88574-38-3 Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alaninate ester 
• 351352-70-0 benzyl N-(N-benzoyl-β-alanyl)-β-alaninate 
• 181638-53-9 3-[4-(N'-tert-Butoxycarbonyl-hydrazino)-4-oxo-butyrylamino]-propionic acid benzyl ester 
• 250233-43-3 2-[4-[3-(benzyloxy)-3-oxopropyl]-8-(3-methylbutylidene)-3-oxo-1-thia-4-azaspiro[4.5]decan-2-yl]-acetic acid 
• 171178-00-0 3-[4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzamido]propionic acid 
• 104571-63-3 Benzyl 3-N-(1-Ethyl-1,4-Dihydro-6,7-Methylenedioxy-4-Oxoquinoline-3-Carbonyl)Aminopropionate 
• 65940-39-8 N,O-dibenzyl β-alanine p-toluene sulphonate 
• 1016170-85-6 methyl 2-[3-(benzyloxy)-3-oxopropylcarbamoyl]-6-methyl-3-phenethyl-1H-indole-5-carboxylate 
• 129524-77-2 C₂₁H₃₂N₂O₅ 
• 1273016-94-6 N-Boc-(S)valine-β-alanine 
• 187279-89-6 4-(2,5-dimethyl-4-methylthiophenyl)-4-ketobutanoyl-β-alanine benzyl ester 

Relevant articles and documents

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

This work takes advantage of one of the hallmarks of cancer, that is, the presence of tumor infiltrating cells of the immune system and leukocyte-secreted enzymes, to promote the activation of an anticancer drug at the tumor site. The peptidomimetic integrin ligand cyclo(DKP-RGD) was found to accumulate on the surface of αvβ3 integrin-expressing human renal cell carcinoma 786-O cells. The ligand was conjugated to the anticancer drug paclitaxel through a Asn-Pro-Val (NPV) tripeptide linker, which is a substrate of neutrophil-secreted elastase. In vitro linker cleavage assays and cell antiproliferative experiments demonstrate the efficacy of this tumor-targeting conjugate, opening the way to potential therapeutic applications.

REAGENTS FOR QUANTITATIVE MASS SPECTROMETRY

In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.

Synthesis of peptides and proteins

Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.