3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

Base Information

Chemical Name:3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole
CAS No.:1163300-02-4
Molecular Formula:C₁₈H₁₀BrClN₄OS
Molecular Weight:445.727
Hs Code.:

Synonyms:3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

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Chemical Property of 3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

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Technology Process of 3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

There total 1 articles about 3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1163299-96-4
3-[6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

: 1163300-02-4
3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

Guidance literature:: 3-[6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole; With bromine; sodium acetate; acetic acid; at 20 ℃;

With ammonia; In water;
DOI:10.1016/j.ejmech.2008.12.019

Reference yield: 81.6%

: 1163300-02-4
3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

: 108-98-5
thiophenol

: C₂₄H₁₅ClN₄OS₂

Guidance literature:: thiophenol; With sodium ethanolate; In ethanol; at 20 ℃; for 2h;

3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole; In ethanol; for 5h; Reflux;
DOI:10.1080/10426507.2015.1012196

Reference yield:

: 1163300-02-4
3-[5-bromo-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl]benzo[d]isoxazole

: 108-98-5
thiophenol

: 3-([5-benzenesulfonyl-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]methyl)benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 2 h / 20 °C

1.2: 5 h / Reflux

2.1: acetic acid; dihydrogen peroxide / 48 h / 20 °C

With dihydrogen peroxide; sodium ethanolate; acetic acid; In ethanol;
DOI:10.1080/10426507.2015.1012196