(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Base Information

• Chemical Name: (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate
• CAS No.: 1536481-20-5
• Molecular Formula: C₁₇H₂₄O₆
• Molecular Weight: 324.374
• Mol file: 1536481-20-5.mol

Synonyms:(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Chemical Property of (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

There total 2 articles about (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl glyoxylate (7633-32-1) + 2,6-dimethylbenzoyloxyacetaldehyde (1536481-30-7) → (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate (1536481-20-5) + 4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Guidance literature:

tert-butyl glyoxylate; 2,6-dimethylbenzoyloxyacetaldehyde; With C₅₀H₃₃F₈NO₄; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

With sodium tetrahydroborate; In 1-methyl-pyrrolidin-2-one; ethanol; at 0 ℃; for 0.5h; Overall yield = 60 %; stereoselective reaction;

DOI:10.1021/ol4036837

Reference yield:

(S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (848821-76-1) + tert-butyl glyoxylate (7633-32-1) + 2,6-dimethylbenzoyloxyacetaldehyde (1536481-30-7) → (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate (1536481-20-5) + 4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate + C38H35F12NO6 (1536481-31-8)

Guidance literature:

(S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol; tert-butyl glyoxylate; 2,6-dimethylbenzoyloxyacetaldehyde; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

With sodium tetrahydroborate; In 1-methyl-pyrrolidin-2-one; ethanol; at 0 ℃; for 0.5h; stereoselective reaction;

DOI:10.1021/ol4036837

upstream raw materials:

(S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol

tert-butyl glyoxylate

2,6-dimethylbenzoyloxyacetaldehyde