(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Base Information

Chemical Name:(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate
CAS No.:1536481-20-5
Molecular Formula:C₁₇H₂₄O₆
Molecular Weight:324.374
Hs Code.:

Synonyms:(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

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Chemical Property of (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

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Technology Process of (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

There total 2 articles about (2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7633-32-1
tert-butyl glyoxylate

: 1536481-30-7
2,6-dimethylbenzoyloxyacetaldehyde

: 1536481-20-5
(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

: 4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

Guidance literature:: tert-butyl glyoxylate; 2,6-dimethylbenzoyloxyacetaldehyde; With C₅₀H₃₃F₈NO₄; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

With sodium tetrahydroborate; In 1-methyl-pyrrolidin-2-one; ethanol; at 0 ℃; for 0.5h; Overall yield = 60 %; stereoselective reaction;
DOI:10.1021/ol4036837

Reference yield:

: 848821-76-1
(S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol

: 7633-32-1
tert-butyl glyoxylate

: 1536481-30-7
2,6-dimethylbenzoyloxyacetaldehyde

: 1536481-20-5
(2R,3R)-4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

: 4-(tert-butoxy)-1,3-dihydroxy-4-oxobutan-2-yl 2,6-dimethylbenzoate

: 1536481-31-8
C₃₈H₃₅F₁₂NO₆

Guidance literature:: (S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol; tert-butyl glyoxylate; 2,6-dimethylbenzoyloxyacetaldehyde; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

With sodium tetrahydroborate; In 1-methyl-pyrrolidin-2-one; ethanol; at 0 ℃; for 0.5h; stereoselective reaction;
DOI:10.1021/ol4036837