Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Base Information

Chemical Name:Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate
CAS No.:136034-04-3
Molecular Formula:C₂₇H₂₇F₂O₅S*Na
Molecular Weight:524.561
Hs Code.:

Synonyms:Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

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Chemical Property of Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

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Technology Process of Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

There total 7 articles about Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 136034-04-3
Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:

Reference yield:

: 135054-71-6
4(R)-Hydroxy-6(S)-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxymethyl]-3,4,5,6-tetrahydro-2H-pyran-2-one

: 136034-04-3
Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:: With sodium hydroxide; In ethanol; at 20 - 25 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: 124655-09-0,407577-54-2
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate

: 136034-04-3
Sodium 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 74 percent / K₂CO₃, 18-Crown-6 / hexamethylphosphoric acid triamide / 12 h / 60 - 85 °C

3: 81 percent / 2N HCl / ethanol; tetrahydrofuran / 24 h / 25 °C

4: 85 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

5: 1N NaOH / ethanol / 1 h / 20 - 25 °C

With pyridine; hydrogenchloride; sodium hydroxide; 18-crown-6 ether; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane;
DOI:10.1021/jm00114a004