4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester
• CAS No.: 75466-96-5
• Molecular Formula: C₄₅H₅₉N₃O₁₈
• Molecular Weight: 929.973

Synonyms:4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

Chemical Property of 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

There total 15 articles about 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Glycine tert-butyl ester (6456-74-2) → 4-Oxo-pentanoic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4R)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester (75466-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 20 h / 70 °C

2: 1.) Hg(CN)2; 2.) Ac₂O-pyridine / 1.) 2h, 40 deg C; 2.) 2h, 20 deg C

With pyridine; mercury(II) cyanide; acetic anhydride; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)98942-2

Reference yield:

Glycine tert-butyl ester (6456-74-2) → 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester (75466-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / dioxane / 20 h / 70 °C

2: 1.) Hg(CN)2; 2.) Ac₂O / 1.) toluene, 2h, 40 deg C; 2.) pyridine, 2h, 20 deg C

With mercury(II) cyanide; acetic anhydride; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)98942-2

Reference yield:

Glycine tert-butyl ester (6456-74-2) → 4-Oxo-pentanoic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-2-[(1S,4R)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester (75466-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 20 h / 70 °C

2: 1.) Hg(CN)2; 2.) Ac₂O, pyridine / 1.) 2h, 40 deg C; 2.) 2h, 20 deg C

With pyridine; mercury(II) cyanide; acetic anhydride; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)98942-2

upstream raw materials:

((S)-2,6-Bis-benzyloxycarbonylamino-5-hydroxy-hexanoylamino)-acetic acid tert-butyl ester

3,4,6-tri-O-acetyl-2-O-levulinoyl-α-D-galactopyranosyl bromide

Glycine tert-butyl ester

[(3R,6S)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

Downstream raw materials:

[(S)-2,6-Bis-benzyloxycarbonylamino-5-((2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-hexanoylamino]-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid

{(2S,5S)-2,6-Bis-benzyloxycarbonylamino-5-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75466-96-5 4-Oxo-pentanoic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4S)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send