5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Base Information

Chemical Name:5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one
CAS No.:1448867-02-4
Molecular Formula:C₂₈H₂₄Cl₂FN₃O₂
Molecular Weight:524.422
Hs Code.:

Synonyms:5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

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Chemical Property of 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

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Technology Process of 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

There total 4 articles about 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448870-39-0
5-(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid

: 1448867-02-4
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 14h; Inert atmosphere;

Reference yield:

: 2106-04-9
3-chloro-2-fluoroaniline

: 1448867-02-4
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 14 h / 20 - 80 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; methanesulfonyl chloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1448870-40-3
5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid methyl ester

: 1448867-02-4
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 14 h / 20 - 80 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;