3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Base Information

• Chemical Name: 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine
• CAS No.: 112141-41-0
• Molecular Formula: C₄₅H₅₀N₆O₉Si
• Molecular Weight: 847.012
• Mol file: 112141-41-0.mol

Synonyms:3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property of 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

There total 2 articles about 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112208-58-9) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-41-0)

Guidance literature:

With triethylamine; In methanol; for 5h; Ambient temperature;

DOI:10.1002/hlca.19940770104

Reference yield: 32.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-39-6) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-41-0) + 2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112208-58-9) + 2',3'-bis-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Guidance literature:

With 1H-imidazole; In pyridine; for 5h; Ambient temperature;

DOI:10.1002/hlca.19940770104

Reference yield: 92.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-41-0) → 3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> (156046-18-3)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 16h; Ambient temperature;

DOI:10.1002/hlca.19940770104

upstream raw materials:

tert-butyldimethylsilyl chloride

5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Downstream raw materials:

3'-O-<(tert-butyl)dimethylsilyl>-N⁶,2'-O-bis-<(tert-butyloxy)carbonyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

5'-O-(monomethoxytrityl)-2'-O-<(tert-butyl)dimethylsilyl>adenosine

3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine