Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester

Base Information

• Chemical Name: Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester
• CAS No.: 320342-71-0
• Molecular Formula: C₁₂H₁₆O₇S₂
• Molecular Weight: 336.387
• Mol file: 320342-71-0.mol

Synonyms:Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester

Chemical Property of Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester

There total 2 articles about Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.9%

coniferal alcohol (458-35-5,32811-40-8,69056-21-9) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 4-((E)-3-hydroxy-propenyl)-2-methoxy-phenyl ester + Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester (320342-71-0)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h;

DOI:10.1016/S0040-4020(00)00873-5

Reference yield:

trans-coniferyl aldehyde (458-36-6) → Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester (320342-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.7 percent / NaBH₄ / ethanol / 0.17 h

2: 60.9 percent / Et₃N / CH₂Cl₂ / 0.5 h

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane; 1: Reduction / 2: Substitution;

DOI:10.1016/S0040-4020(00)00873-5

Reference yield: 84.9%

Methanesulfonic acid 4-((E)-3-methanesulfonyloxy-propenyl)-2-methoxy-phenyl ester (320342-71-0) → (E)-2-methoxy-4-(1-propenyl)phenol (5932-68-3)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/S0040-4020(00)00873-5

upstream raw materials:

coniferal alcohol

methanesulfonyl chloride

trans-coniferyl aldehyde

Downstream raw materials:

(E)-2-methoxy-4-(1-propenyl)phenol

(-)-licarin A

trans-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran

(+)-licarin A