4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

Base Information

Chemical Name:4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone
CAS No.:147196-71-2
Molecular Formula:C₁₈H₂₆O₃Si
Molecular Weight:318.488
Hs Code.:

Synonyms:4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

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Chemical Property of 4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

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Technology Process of 4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

There total 6 articles about 4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 147196-70-1
4-Hydroxy-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

: 147196-71-2
4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jo00060a057

Reference yield:

: 60739-53-9
4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone

: 147196-71-2
4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1) CH₃*LiBr / 1) THF, diethyl ether, room temp., 4 h, 2) THF, room temp., 7 h

2: 97 percent / PPTS / ethanol / 3 h / Heating

3: 91 percent / oxalyl chloride, DMSO / tetrahydrofuran / 0.25 h / -60 - -50 °C

4: 98 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

With oxalyl dichloride; pyridinium p-toluenesulfonate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00060a057

Reference yield:

: 556-48-9
1,4-Cyclohexanediol

: 147196-71-2
4-(2-Tetrahydropyranyloxy)-4-(4-(trimethylsilyl)-1,3-butadiynyl)-1-cyclohexanone

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / PPTS / tetrahydrofuran / 6 h / Ambient temperature

2: 87 percent / oxalyl chloride, DMSO / tetrahydrofuran / 0.25 h / -60 - -50 °C

3: 1) CH₃*LiBr / 1) THF, diethyl ether, room temp., 4 h, 2) THF, room temp., 7 h

4: 97 percent / PPTS / ethanol / 3 h / Heating

5: 91 percent / oxalyl chloride, DMSO / tetrahydrofuran / 0.25 h / -60 - -50 °C

6: 98 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

With oxalyl dichloride; pyridinium p-toluenesulfonate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00060a057