1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

Base Information

Chemical Name:1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole
CAS No.:226940-24-5
Molecular Formula:C₃₈H₃₇N₃O₈Si
Molecular Weight:691.813
Hs Code.:

Synonyms:1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

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Chemical Property of 1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

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Technology Process of 1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

There total 5 articles about 1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 93-97-0
benzoic acid anhydride

: 226940-23-4
1-(β-D-5'-tert-Butyldiphenylsilyloxyribofuranose)-5-nitroimidazole

: 226940-24-5
1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

Guidance literature:: With pyridine; dmap; Ambient temperature;
DOI:10.1055/s-1999-3500

Reference yield:

: 39110-68-4
2,3,5-tri-O-acetyl-D-ribofuranosyl bromide

: 226940-24-5
1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NH₄OH, AgNO₃, 2.) 4 Angstroem molecular sieves / 1.) H₂O, 10 min, 2.) xylene, reflux, 1 h

2: 95 percent / Et₃N, H₂O / methanol / Ambient temperature

3: 72 percent / imidazole / dimethylformamide / Ambient temperature

4: 87 percent / pyridine, DMAP / Ambient temperature

With pyridine; 1H-imidazole; dmap; ammonium hydroxide; 4 A molecular sieve; water; silver nitrate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-1999-3500

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 226940-24-5
1-(β-D-5'-tert-Butyldiphenylsilyloxy-2',3'-di-O-benzoylribofuranose)-5-nitroimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / imidazole / dimethylformamide / Ambient temperature

2: 87 percent / pyridine, DMAP / Ambient temperature

With pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;
DOI:10.1055/s-1999-3500