t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate

Base Information

• Chemical Name: t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate
• CAS No.: 1376191-12-6
• Molecular Formula: C₂₁H₂₅FN₄O₆S
• Molecular Weight: 480.517

Synonyms:t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate

Chemical Property of t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate

There total 2 articles about t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-fluoro-3-nitrobenzene-1-sulfonyl chloride (6668-56-0) + 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine (170911-92-9) → t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate (1376191-12-6)

Guidance literature:

With pyridine; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm300178u

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate (1376191-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid

2: pyridine

With pyridine; chlorosulfonic acid;

Reference yield: 82.0%

(R)-N1,N1-dimethyl-4-(phenylthio)butane-1,3-diamine (870812-32-1) + t-butyl 4-[4-(4-fluoro-3-nitrophenylsulfonamido)phenyl]piperazine-1-carboxylate (1376191-12-6) → (R)-tert-butyl 4-(4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonamido)phenyl)piperazine-1-carboxylate (1391108-53-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm4001105

upstream raw materials:

4-fluoro-3-nitrobenzene-1-sulfonyl chloride

4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

ortho-nitrofluorobenzene

Downstream raw materials:

(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitro-N-[4-(piperazin-1-yl)phenyl]benzenesulfonamide

(R)-N-(4-{4-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}phenyl)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrobenzenesulfonamide

4-(4-chlorophenyl)-1-[(S)-3,4-dihydroxybutyl]-3-(3-{4-[4-(4-{[(R)-4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrophenylsulfonamido)phenyl]piperazin-1-yl}phenyl)-N-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrole-2-carboxamide

C₄₃H₄₅ClN₈O₄S₂

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